ABSTRACT
Taller height, family history of breast cancer, greater number of years of potential fertility and nulliparity are established non-modifiable risk factors for postmenopausal breast cancer. Greater adherence to the World Cancer Research Fund/American Institute for Cancer Research (WCRF/AICR) diet, physical activity and body weight recommendations has previously been shown to be associated with lower breast cancer risk. However, no prior studies have evaluated whether women with non-modifiable risk factors receive similar benefits from recommendation adherence compared to women without these risk factors. In the Iowa Women's Health Study prospective cohort, we investigated whether associations of WCRF/AICR recommendation adherence differed by the presence/absence of non-modifiable breast cancer risk factors. Baseline (1986) questionnaire data from 36,626 postmenopausal women were used to create adherence scores for the WCRF/AICR recommendations (maximum score=8.0). Overall and single recommendation adherence in relation to breast cancer risk (n=3,189 cases) across levels of non-modifiable risk factors were evaluated using proportional hazards regression. Mean adherence score was 5.0 points (range: 0.5–8.0). Higher adherence scores (score ≥6.0 vs. ≤3.5, HR=0.76, 95% CI=0.67–0.87), and adherence to the individual recommendations for body weight and alcohol intake were associated with a lower breast cancer incidence. While not statistically significant among women with more non-modifiable risk factors (score ≥6.0 vs. ≤3.5, HR=0.76, 95% CI=0.36–1.63), hazard ratios were comparable to women with the no non-modifiable risk factors (score ≥6.0 vs. ≤3.5, HR=0.74, 95% CI=0.49–0.93) (p-interaction=0.57). WCRF/AICR recommendation adherence is associated with lower breast cancer risk, regardless of non-modifiable risk factor status. This article is protected by copyright. All rights reserved.
from Cancer via ola Kala on Inoreader http://ift.tt/1RBfqYt
via IFTTT
Δεν υπάρχουν σχόλια:
Δημοσίευση σχολίου