A novel bispecific antibody, BiSS, with potent anti-cancer activities.

A novel bispecific antibody, BiSS, with potent anti-cancer activities.

Cancer Biol Ther. 2016 Feb 1;:0

Authors: Dong B, Zhou C, He P, Li J, Chen S, Miao J, Li Q, Wang Z

Abstract
One of the most active fields in cancer immunotherapy is the study of bispecific antibodies, which engage immune cells to kill cancer cells. However, a variety of issues are associated with most of current bispecific antibody formats. In this study, we present a novel bispecific antibody, BiSS (Bispecific antibody with Single domain, Single domain antibodies), which was constructed by linking two single domain antibodies, anti-CEA and anti-CD16, in tandem. Unlike most other bispecific antibodies, the BiSS antibody can be expressed and purified from E.coli in large quantities. By recruiting natural killer cells (NK cells) to CEA-positive cancer cells, BiSS led to cancer cell death in vitro. In xenograft models, the BiSS protein blocked cancer progression. The data suggested that the single domain-based bispecific antibody BiSS was functional and can be potentially applied to a broad range of immunotherapies.

PMID: 26828900 [PubMed - as supplied by publisher]

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