An assessment of intrafraction breathing motion on left anterior descending artery dose during left-sided breast radiation therapy

Publication date: Available online 13 February 2016
Source:International Journal of Radiation Oncology*Biology*Physics
Author(s): Omar El-Sherif, Edward Yu, Ilma Xhaferllari, Stewart Gaede

Teaser

Using four-dimensional computed tomography and deformable dose accumulation, we assessed the variation caused by breathing motion in the estimated dose to the heart, left-ventricle, and left anterior descending artery (LAD) of left-sided breast cancer patients. The LAD showed substantial variation (± 8.7 Gy) in dose due to breathing. In light of this, we suggest the use of 4D-CT and dose accumulation for future clinical studies looking at the relationship between LAD dose and cardiac toxicity.


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