Diagnosis and management of typical and atypical lung carcinoids

Publication date: April 2016
Source:Critical Reviews in Oncology/Hematology, Volume 100
Author(s): Sara Pusceddu, Giuseppe Lo Russo, Marianna Macerelli, Claudia Proto, Milena Vitali, Diego Signorelli, Monica Ganzinelli, Paolo Scanagatta, Leonardo Duranti, Annalisa Trama, Roberto Buzzoni, Giuseppe Pelosi, Ugo Pastorino, Filippo de Braud, Marina Chiara Garassino
An estimated 20% to 30% of all neuroendocrine tumours originate in the bronchial tree and lungs. According to the 2015 World Health Organization categorization, these tumours are separated into four subtypes characterized by increasing biological aggressiveness: typical carcinoid, atypical carcinoid, large-cell neuroendocrine carcinoma and small-cell carcinoma. Although typical and atypical lung carcinoids account for less than 1–5% of all pulmonary malignancies, the incidence of these neoplasms has risen significantly in recent decades. Surgery is the treatment of choice for loco-regional disease but for advanced lung carcinoids there is no recognized standard of care and successful management requires a multidisciplinary approach. The aim of this review is to provide a useful guide for the clinical management of lung carcinoids.



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