Pre-diagnostic body size and breast cancer survival in the E3N cohort study

Abstract

Obesity has been associated with poor breast cancer prognosis, however most studies have focused on Body Mass Index (BMI) and few have considered the distribution of adipose tissue. We investigated associations between pre-diagnostic adiposity and breast cancer survival, considering BMI, waist and hip circumferences (WC and HC), and waist-to-hip ratio (WHR).

Analyses included 3,006 women from the French E3N prospective cohort study diagnosed with primary invasive breast cancer between 1995 and 2008. We investigated overall, breast cancer-specific, and disease-free survival, overall and according to stage, menopausal and hormonal status and year of diagnosis, using Cox proportional hazard models adjusted for tumor characteristics and lifestyle risk factors.

Women with a pre-diagnostic HC>100 cm were at increased risk of death from all causes (Hazard Ratio (HR)_>100vs<95cm=1.38, 95% Confidence Interval (CI)=1.02-1.86, P_trend=0.02) and from breast cancer (HR_>100vs<95cm=1.50, CI=1.03-2.17, P_trend=0.03), and of second invasive cancer event (HR_>100vs<95cm=1.36, CI=1.11-1.67, P_trend=0.002), compared to those with HC <95 cm. Associations were stronger after adjustment for BMI. BMI, WC and WHR were not associated with survival after breast cancer.

Our study underlines the importance of going beyond BMI when studying the association between adiposity and breast cancer survival. Further studies should be conducted to confirm our results on hip circumference. This article is protected by copyright. All rights reserved.

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