The role of microRNA-26a in human cancer progression and clinical application

Abstract

MicroRNAs, a class of endogenous, small (18–25 nucleotides) noncoding RNAs, regulate gene expression by directly binding to the 3′-untranslated regions of target messenger RNAs. Evidence has shown that alteration of microRNAs is involved in cancer initial and progression. MicroRNA-26a is commonly dysregulated in diverse cancers and is involved in various biological processes, including proliferation, migration, invasion, angiogenesis, and metabolism by targeting multiple mRNAs. This review summarizes current research on the physiology and pathological functions of miR-26a and its applications for clinical therapy.

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