The Time To Progression Ratio: a new individualized volumetric parameter for early detection of clinical benefit of targeted therapies

Detecting signs of efficacy in early phase clinical trials is essential for efficient drug development. The TTP ratio is a novel endpoint that incorporates volumetrics and an intra-patients control to determine treatment efficacy. Response according to TTP ratio was correlated to Overall Survival and identified patients within the RECIST Stable Disease group who had a longer Overall Survival.

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