18F-fluorodeoxyglucose-positron emission tomography can quantify and predict esophageal injury during radiation therapy

Publication date: Available online 21 July 2016
Source:International Journal of Radiation Oncology*Biology*Physics
Author(s): Joshua S. Niedzielski, Jinzhong Yang, Zhongxing Liao, Daniel R. Gomez, Francesco Stingo, Radhe Mohan, Mary K. Martel, Tina M. Briere, Laurence E. Court
We investigated the use of mid-treatment FDG-PET as an objective quantification of radiation esophagitis for NSCLC patients undergoing chemoradiotherapy. FDG-PET uptake was normalized to low-dose regions of the esophagus to create localized radiation response metrics. We found normalized PET uptake was highly correlated to esophagitis grade, both during the PET study, and by treatment completion. In addition, PET uptake can predict eventual esophagitis from patients who are asymptomatic during the mid-treatment PET scan.



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