Higher Rate of Severe Toxicities in Obese Patients Receiving dose-dense (dd) Chemotherapy according to Unadjusted Body Surface Area- Results of the Prospectively Randomized GAIN study

Obese patients receiving dose-dense (dd) chemotherapy according to their real body surface area (BSA) are at higher risk for severe toxicities. However, efficacy is not influenced by relative total dose intensity. Therefore, dose adjustment of dd chemotherapy is warranted in obese patients to avoid complications.

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