Long non-coding RNA UCA1 contributes to the progression of oral squamous cell carcinoma via regulating WNT/β-catenin signaling pathway

Abstract

With the development of the functional genomics studies, a mass of long non-coding RNAs (LncRNA) were discovered from the human genome. LncRNAs serve as pivotal regulator of genes, which are able to generate LncRNA-binding-protein complexes to modulate a great many of genes. Recently, the LncRNA urothelial carcinoma-associated 1 (UCA1) has been revealed to be dysregulated, which plays a critical role in the development of a few cancers. However, the role of biology and clinical signification of UCA1 in the tumorigenesis of oral squamous carcinoma (OSCC) remain unknown. Hereof, we found that UCA1 expression levels were upregulated aberrantly in TSCC tissues and associated with lymph node metastasis (LNM) and TNM stage. We explored the expression, function and molecular mechanism of LncRNA-UCA1 in the oral squamous cell carcinoma. In the present work, we demonstrated that UCA1 silencing suppressived the proliferation and metastasis, induced apoptosis of OSCC cell lines in vitro and in vivo, which might be related to the activation level of WNT/β-catenin signaling pathway. To sum up, our research results emphasize the pivotal role of UCA1 in the oncogenesis of OSCC and, revealed a novel LncRNA UCA1-β-catenin-WNT signaling pathway regulatory network, which may contribute to our understanding in the pathogenesis of OSCC and discover a viable LncRNA-directed diagnostic and therapeutic strategy for this fatal disease.

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