Reproducibility and uptake time dependency of volume-based parameters on FDG-PET for lung cancer

Abstract

Background

Volume-based parameters, such as metabolic tumor volume (MTV) and total lesion glycolysis (TLG), on F-18 fluorodeoxyglucose (FDG) positron emission tomography (PET) are useful for predicting treatment response in nonsmall cell lung cancer (NSCLC). We aimed to examine intra- and inter-operator reproducibility to measure the MTV and TLG, and to estimate their dependency on the uptake time.

Methods

Fifty NSCLC patients underwent preoperative FDG-PET. After an injection of FDG, the whole body was scanned twice: at the early phase (61.4 ± 2.8 min) and delayed phase (117.7 ± 1.6 min). Two operators independently defined the tumor boundary using three different delineation methods: (1) the absolute SUV threshold method (MTV_p and TLG_p; p = 2.0, 2.5, 3.0, 3.5), (2) the fixed% SUVmax threshold method (MTV_q% and TLG_q%; q = 35, 40, 45), and (3) the adaptive region-growing method (MTV_ARG and TLG_ARG). Parameters were compared between operators and between phases.

Results

Both the intra- and inter-operator reproducibility were high for all parameters using any method (intra-class correlation > 0.99 each). MTV_3.0 and MTV_3.5 resulted in a significant increase from the early to delayed phase (P < 0.05 for both), whereas MTV_2.0 and MTV_2.5 neither increased nor decreased (P = n.s.). All of the MTV_q% values significantly decreased over time (P < 0.01), whereas MTV_ARG and TLG with any delineation method increased significantly (P < 0.05).

Conclusions

High reproducibility of MTV and TLG was obtained by all of the methods used. MTV_2.0 and MTV_2.5 were the least sensitive to uptake time, and may be good alternatives when we compare images acquired with different uptake times, although applying constant uptake time is important for volume measurement.

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