Genetic Variants in CD44 and MAT1A Confer Susceptibility to Acute Skin Reaction in Breast Cancer Patients Undergoing Radiotherapy

Publication date: Available online 20 September 2016
Source:International Journal of Radiation Oncology*Biology*Physics
Author(s): Kamalesh Dattaram Mumbrekar, Satish Rao Bola Sadashiva, Shama Prasada Kabekoddu, Donald Jerard Fernandes, Bejadi Manjunath Vadhiraja, Tomo Suga, Yoshimi Shoji, Fumiaki Nakayama, Takashi Imai, Kapaettu Satyamoorthy
PurposeHeterogeneity in radiotherapy (RT) induced normal tissue toxicity is observed in 10% of cancer patients, limiting the therapeutic outcome. Besides, treatment related factors, normal tissue adverse reactions are also manifested from genetic alterations in genes of distinct pathways majorly involving DNA damage-repair, inflammatory cytokine, cell cycle regulation and antioxidant response. Therefore, the common sequence variants in these radioresponsive genes may modify the severity of normal tissue toxicity and identification of the same may have clinical relevance as a predictive biomarker.



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