Salvage Radiotherapy Dose Response for Biochemical Failure of Prostate Cancer after Prostatectomy - A Multi-Institutional Observational Study

Publication date: Available online 3 September 2016
Source:International Journal of Radiation Oncology*Biology*Physics
Author(s): Thomas M. Pisansky, Shree Agrawal, Daniel A. Hamstra, Bridget F. Koontz, Stanley L. Liauw, Jason A. Efstathiou, Jeff M. Michalski, Felix Y. Feng, Matthew C. Abramowitz, Alan Pollack, Mitchell S. Anscher, Drew Moghanaki, Robert B. Den, Kevin L. Stephans, Anthony L. Zietman, W. Robert Lee, Michael W. Kattan, Andrew J. Stephenson, Rahul D. Tendulkar
Ten academic centers in the United States pooled individual prostate cancer patient data into a centralized database in order to describe the effects of salvage radiotherapy for detectable serum prostate-specific antigen after prostatectomy. The outcomes of 1108 such patients are presented, focusing on the relationship of radiotherapy dose with selected endpoints. The incidence of biochemical failure after radiotherapy was reduced when ≥66.0 Gy was prescribed, supporting higher-dose salvage radiotherapy whenever feasible.



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