Tumor-associated macrophages (TAMs) are a major cellular component of numerous tumor types. TAM-targeted therapies include depletion strategies, inhibiting their effector functions, or reprogramming towards an anti-tumorigenic phenotype, with varying degrees of efficacy. Here we review preclinical and clinical strategies to target macrophages in cancer, and discuss potential explanations for why some strategies are effective while other approaches have shown limited success.
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