ABO blood group and risk of glioma

<span class="paragraphSection">Age, radiation, and rare hereditary syndromes are the only well-established risk factors for glioma.^{<a href="#CIT0001" class="reflinks">1</a>,<a href="#CIT0002" class="reflinks">2</a>} Several retrospective studies in the 1950s and 1960s investigated the relationship between ABO blood group and glioma occurrence; although some reported decreased risk of glioma in patients of group O blood, others found no association.^{<a href="#CIT0003" class="reflinks">3</a>,<a href="#CIT0004" class="reflinks">4</a>} Since then, our group showed that O blood type is inversely associated with pancreatic cancer, and non-O type is inversely related to non-melanoma skin cancer.^{<a href="#CIT0005" class="reflinks">5</a>,<a href="#CIT0006" class="reflinks">6</a>} We therefore analyzed the association between ABO blood group and risk of glioma in 2 large, prospective cohort studies, the Nurses' Health Study (NHS) and the Health Professionals Follow-up Study (HPFS).</span>

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