Analysis of physical characteristics of Tumor Treating Fields for human glioblastoma

Abstract

Tumor Treating Fields (TTFields) therapy is an approved treatment that has known clinical efficacy against recurrent and newly diagnosed glioblastoma. However, the distribution of the electric fields and the corresponding pattern of energy deposition in the brain are poorly understood. To evaluate the physical parameters that may influence TTFields, postacquisition MP-RAGE, T1 and T2 MRI sequences from a responder with a right parietal glioblastoma were anatomically segmented and then solved using finite-element method to determine the distribution of the electric fields and rate of energy deposition at the gross tumor volume (GTV) and other intracranial structures. Electric field–volume histograms (EVH) and specific absorption rate–volume histograms (SARVH) were constructed to numerically evaluate the relative and/or absolute magnitude volumetric differences between models. The electric field parameters E_AUC, V_E150, E_95%, E_50%, and E_20%, as well as the SAR parameters SAR_AUC, V_SAR7.5, SAR_95%, SAR_50%, and SAR_20%, facilitated comparisons between models derived from various conditions. Specifically, TTFields at the GTV were influenced by the dielectric characteristics of the adjacent tissues as well as the GTV itself, particularly the presence or absence of a necrotic core. The thickness of the cerebrospinal fluid on the convexity of the brain and the geometry of the tumor were also relevant factors. Finally, the position of the arrays also influenced the electric field distribution and rate of energy deposition in the GTV. Using EVH and SARVH, a personalized approach for TTFields treatment can be developed when various patient-related and tumor-related factors are incorporated into the planning procedure.

The electric field–volume histogram (A), electric field map (B), specific absorption rate–volume histogram (C), and specific absorption rate map (D) were generated according to the conventional transducer array placement. The highest area under the curve value for the electric field was found at the scalp and skull, whereas the lowest was detected at the orbits, bilateral ventricles, and brainstem. The highest area under the curve value for the specific absorption rate was found at the layer of cerebrospinal fluid between cortex and dura, the gross tumor volume, and skull, whereas the lowest was found in the orbits, cerebellum, and the orbits.

from Cancer via ola Kala on Inoreader http://ift.tt/2rwgfeb
via IFTTT