Cellular identity crisis: antiandrogen resistance by lineage plasticity.

Cellular identity crisis: antiandrogen resistance by lineage plasticity.

Cancer Biol Ther. 2017 May 05;:0

Authors: Tuerff D, Sissung T, Figg WD

Abstract
A recent publication in Science demonstrates the ability of prostate cancer cells to switch lineages from one that is dependent on androgen signaling to a cell type that is not. Known as lineage plasticity, this phenomenon is driven by the transcription factor SOX2 in RB1 and TP53-deficient prostate cancer. SOX2 is a potential prognostic marker and therapeutic target in castration resistant prostate cancer.

PMID: 28475401 [PubMed - as supplied by publisher]

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