miR-337 can be a key negative regulator in melanoma.

miR-337 can be a key negative regulator in melanoma.

Cancer Biol Ther. 2017 May 12;:0

Authors: Xiao W, Yao E, Zheng W, Tian F, Tian L

Abstract
Incidence of melanoma is increasing annually worldwide. There remains a lack of suitable treatment methods which can significantly improve the five-year survival rates of patients. It is established that micro RNAs (miRNAs) have important roles in the diagnosis and treatment of cancer. MiR-337 had been reported to regulate the development of variety of cancers, as a cancer suppressive factor. In our research we found that miR-337 had a lower expression in melanoma than adjacent tissues. The patients who had a lower miR-337 also got a worse survival. MiR-337 could target STAT3 to regulate the occurrence and development of melanoma. In summary, our findings suggest that the miR-337/STAT3 axis may serve as a potential target for the treatment of melanoma.

PMID: 28498028 [PubMed - as supplied by publisher]

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