Tumor Microenvironment: No Effector T Cells without Dendritic Cells

Publication date: 8 May 2017
Source:Cancer Cell, Volume 31, Issue 5
Author(s): Christina Pfirschke, Marie Siwicki, Hsin-Wei Liao, Mikael J. Pittet
Successful antitumor immunity is thought to require T cell entry into tumors, though mechanisms regulating this process remain unclear. In this issue of Cancer Cell, Spranger et al. indicate that chemokines produced by intratumoral Batf3 dendritic cells are critical for effector T cell recruitment. The findings have implications for immunotherapy.

Teaser

Successful antitumor immunity is thought to require T cell entry into tumors, though mechanisms regulating this process remain unclear. In this issue of Cancer Cell, Spranger et al. indicate that chemokines produced by intratumoral Batf3 dendritic cells are critical for effector T cell recruitment. The findings have implications for immunotherapy.


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