Sexual Quality of Life Following Prostate Intensity Modulated Radiotherapy (IMRT) with a Rectal/Prostate Spacer: Secondary Analysis of a Phase III Trial

Publication date: Available online 19 July 2017
Source:Practical Radiation Oncology
Author(s): Daniel A Hamstra, Neil Mariados, John Sylvester, Dhiren Shah, Eric Gross, Richard Hudes, David Beyer, Steven Kurtzman, Jeffrey Bogart, R. Alex Hsi, Michael Kos, Rodney Ellis, Mark Logsdon, Shawn Zimberg, Kevin Forsythe, Hong Zhang, Edward Soffen, Patrick Francke, Constantine Mantz, Peter Rossi, Theodore DeWeese, Stephanie Daignault-Newton, Benjamin W Fischer-Valuck, Anupama Chundury, Hiram A. Gay, Walter Bosch, Jeff Michalski
A phase 3 trial was performed using an absorbable hydrogel (SpaceOAR System®) to provide space between the prostate and rectum for men receiving image-guided prostate IMRT. Based upon a secondary analysis the spacer reduced penile bulb dose, penile bulb doses was correlated with erectile dysfunction, and in those with adequate sexual QOL at baseline the use of Spacer was associated with clinically meaningful better sexual QOL and decreased erectile dysfunction.



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