MACF1, a novel potential target in cancer

Abstracts

Cancer is a polygenic disease characterized by uncontrolled growth of normal body cells, which exhibits deregulation of cell cycle as well as resistance to apoptosis and leads to metastasize into other parts of the body. The spectraplakin protein, microtubule actin cross-linking factor 1 (MACF1) plays an essential function in various cellular processes including cell proliferation, migrations, signaling transduction and embryo development. MACF1 is also involved in processes such as metastatic invasion in which cytoskeleton organization is a critical element that contributes to tumor progression in various human cancers. Aberrant expression of MACF1 initiates the tumor cell proliferation, migrations and metastasis in numerous cancers such as breast cancer, colon cancer, lung cancer and glioblastoma. In this review, we summarized the current knowledge of MACF1 and its critical role in different human cancer. It will be helpful for researchers to investigate the novel functional role of MACF1 in human cancers and as a potential target that enhances the efficacy of therapeutic treatment modalities.

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