TRAC(ERx)-ing lung cancer evolution

Because cancer cells constantly accrue a variety of genetic alterations, subclones arising from founder clones show heterogeneity in their genetic makeup. Cancer cells are exposed to a variety of selection pressures induced by decreased blood supply, hypoxia, and treatment-related effects. This leads to the selection and expansion of subclones with genetic makeup that is ideal for continued survival. Studying the evolution of cancer through multi-regional sampling of tumors and next-generation sequencing technologies can greatly advance our understanding of the selection pressures that operate in cancer, and the molecular mechanisms through which cancers adapt to them. This information has the potential to improve outcomes in the clinic.

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