Japanese genome-wide association study identifies a significant colorectal cancer susceptibility locus at chromosome 10p14

Summary

Genome wide association studies are a powerful tool for searching for disease susceptibility loci. Several studies identifying SNPs connected intimately to the onset of colorectal cancer (CRC) have been published, but there are few reports of genome-wide association studies in Japan. To identify genetic variants that modify the risk of CRC oncogenesis, especially in the Japanese population, we performed a multi-stage genome wide association study using a large number of samples: 1,846 CRC cases and 2,675 controls. We identified four SNPs (rs7912831, rs4749812, rs7898455, and rs10905453) in chromosome region 10p14 associated with CRC; however, there are no coding or non-coding genes within this region of fairly extensive linkage disequilibrium (a 500 kb block) on 10p14. Our study revealed that the 10p14 locus is a significant CRC susceptibility region in the Japanese population, in accordance with multiple studies beyond this race.

This article is protected by copyright. All rights reserved.

http://ift.tt/2eDWNHU