The Notch-3 receptor: a molecular switch to tumorigenesis?

Publication date: Available online 1 September 2017
Source:Cancer Treatment Reviews
Author(s): Shakeel Inder, Sinead O'Rourke, Niamh McDermott, Rustom Manecksha, Stephen Finn, Thomas Lynch, Laure Marignol
The Notch pathway is a highly conserved pathway increasingly implicated with the progression of human cancers. Of the four existing receptors associated with the pathway, the deregulation in the expression of the Notch-3 receptor is associated with more aggressive disease and poor prognosis. Selective targeting of this receptor has the potential to enhance current anti-cancer treatments. Molecular profiling strategies are increasingly incorporated into clinical decision making. This review aims evaluate the clinical potential of Notch-3 within this new era of personalised medicine.



http://ift.tt/2iR6jsf