Alternatives to Standard Fractionation Radiation Therapy After Lumpectomy

Publication date: January 2018
Source:Surgical Oncology Clinics of North America, Volume 27, Issue 1
Author(s): Nisha Ohri, Bruce G. Haffty

Teaser

Adjuvant whole-breast irradiation (WBI) after lumpectomy has been an established standard of care for decades. Standard-fractionation WBI delivered over 5 to 7 weeks can achieve durable tumor control with low toxicity but can be inconvenient for patients and cost ineffective. Hypofractionated WBI can be completed in 3 to 4 weeks and, based on long-term randomized data, is the preferred standard of care in select patients. Accelerated partial-breast irradiation can be delivered using even shorter treatment regimens. Although the available data on accelerated partial-breast irradiation is more limited, early results suggest it is an effective alternative to WBI in select patients.


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