Cancers, Vol. 9, Pages 159: Genomic Destabilization Triggered by Replication Stress during Senescence

Cancers, Vol. 9, Pages 159: Genomic Destabilization Triggered by Replication Stress during Senescence

Cancers doi: 10.3390/cancers9110159

Authors: Yusuke Minakawa Atsuhiro Shimizu Yusuke Matsuno Ken-ichi Yoshioka

Most cancers develop after middle age, and are often associated with multiple mutations and genomic instability, implying that genomic destabilization is critical for age-related tumor development. In this manuscript, we review current knowledge regarding (1) the senescent cellular background, which is associated with a higher risk of genomic destabilization; and (2) the contributions of genomic destabilization to cancer development.

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