Response

Because of its increased convenience and decreased cost, once-daily hypofractionated radiotherapy (HFX; 2.25 Gy/fraction) has been adopted over other altered-fractionation schedules in the United States for the management of early-stage glottic cancer. In our patterns-of-care analysis, we found that over 80% of patients were treated with either hypofractionation (2.25 Gy/fraction) or conventional fractionation (CFX; 2.0 Gy/fraction); utilization rates of other altered-fractionation regimens were 2.6% or less. Given the low utilization rates of fractionation schedules not recommended by the National Comprehensive Cancer Network guidelines, we did not compare other altered-fractionation schedules to CFX. Therefore, we were not able to make conclusions regarding the optimal radiotherapy treatment schedule; we could only conclude that our findings suggest that HFX is superior to CFX.

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