Πέμπτη 30 Νοεμβρίου 2017

Surviving ovarian cancer: an affair between defective DNA repair and RB1

Detailed clinical and molecular evaluation of large cohorts of exceptional survivors provide an unprecedented opportunity to identify mechanisms underlying long term survival that can drive future therapeutic approaches and biomarker development. Exceptional survivors of high-grade serous ovarian cancer demonstrate concurrent disruption of homologous recombination DNA repair and retinoblastoma protein.



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