Associations of Genetic Variations in the Seed Regions of MicroRNAs with Acute Adverse Events and Survival in Patients with Rectal Cancer Receiving Postoperative Chemoradiotherapy

Publication date: Available online 21 December 2017
Source:International Journal of Radiation Oncology*Biology*Physics
Author(s): Ying Huang, Yanru Feng, Hua Ren, Meng Zhang, Hongmin Li, Yan Qiao, Ting Feng, Jie Yang, Weihu Wang, Shulian Wang, Yueping Liu, Yongwen Song, Yexiong Li, Jing Jin, Wen Tan, Dongxin Lin
PurposeThe aim of this study was to investigate the associations between single nucleotide polymorphisms (SNPs) in the seed regions of microRNAs and acute adverse events (AEs) and survival in patients with rectal cancer receiving postoperative chemoradiotherapy.Methods and MaterialsEighteen SNPs were genotyped in 365 patients with rectal cancer receiving postoperative chemoradiotherapy. The associations between genotypes and AEs were estimated by odds ratios (ORs) and 95% confidence intervals (CIs), which were computed by using multivariate logistic regression models. The hazard ratios (HRs) and 95% CIs to assess death of patients for different genotypes were calculated by Cox proportional regression models. Overall survival (OS) and disease-free survival (DFS) of patients with different genotypes were estimated by Kaplan-Meier plot and the statistical significance was determined by using log-rank test.ResultsIn these patients, the most common grade ≥ 2 AEs were diarrhea (44.1%), leukopenia (29.6%) and dermatitis (18.9%). We found that, with false discovery rate (FDR) correction, SNP rs2273626 was significantly associated with a decreased risk of grade ≥ 2 leukopenia (OR = 0.48, 95% CI = 0.31–0.74; P = 0.0009). We also found that SNP rs202195689 was associated with OS and DFS in patients receiving postoperative chemoradiotherapy, with the HRs for death being 2.02 (95% CI = 1.36–3.01; P = 0.0006) and 1.91 (95% CI = 1.36–2.70; P = 0.0002), respectively. However, no significant association between these SNPs with diarrhea and dermatitis was observed.ConclusionsThese results suggest that rs2273626 and rs202195689 in microRNA seed regions might serve as independent biomarkers for predicting AEs and prognosis in patients with rectal cancer receiving postoperative chemoradiotherapy. Independent replication of these findings is required to confirm these results.

Teaser

MicroRNAs play a key role in posttranscriptional regulation of mRNA and multiple cellular biological processes. We analyzed 18 SNPs in microRNA seed regions and identified two SNPs associated with acute adverse events and survival time in patients with rectal cancer receiving CAP-based chemoradiotherapy. These SNPs might serve as independent biomarkers for predicting acute adverse events and prognosis in patients with rectal cancer. Independent replication studies are required to confirm these results.


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