Abstract
Objective
Cancer patients, particularly those prescribed oral oncolytic medications, face treatment side effects, and temporary and permanent stoppages of treatment. This research examines how events during treatment affect patients' beliefs regarding oral oncolytic medications.
Methods
272 cancer patients initiating one of 28 oral oncolytic agents were followed for 12 weeks. Assessments of Beliefs About Medications Questionnaire (BMQ), symptoms, physical function, and depression measures were performed during telephone interviews at intake (medication start) and 4, 8, and 12 weeks. Electronic medical record audits identified dates of temporary and permanent medication stoppages. Linear mixed effects models were used for longitudinal analyses of the BMQ scores in relation to patient characteristics, symptom severity, and medication stoppages.
Results
Over the initial 12 weeks beliefs about the necessity of oral medications increased, concerns decreased, and interference of medications with daily lives increased. Permanent stoppage of a medication predicted significant declines in beliefs about its necessity over time. Male patients, those less educated, those reporting higher symptom severity, and experiencing temporary stoppages had greater concerns. Interference of medications with daily life was higher for males, increased with higher symptom severity, and differed by drug category.
Conclusions
Patients' beliefs in the necessity of their oral medication were affected only by a permanent drug stoppage. Symptom severity, education, and patient sex affected patients' beliefs about their concerns with their medications, and the interference medications posed for their daily lives. Interventions may need to target the distinct dimensions of beliefs during treatment with oral oncolytic agents.
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