Long Non-coding RNA CEBPA-AS1 Correlates with Poor Prognosis and Promotes Tumorigenesis via CEBPA/Bcl2 in Oral Squamous Cell Carcinoma.

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Long Non-coding RNA CEBPA-AS1 Correlates with Poor Prognosis and Promotes Tumorigenesis via CEBPA/Bcl2 in Oral Squamous Cell Carcinoma.

Cancer Biol Ther. 2017 Dec 27;:0

Authors: Guo Y, Ma Y, Hu X, Song R, Zhu L, Zhong M

Abstract
Oral squamous cell carcinoma (OSCC) is one of the most aggressive and lethal malignancies affecting the head and neck region with a general 5-year survival rate about 50%. Long non-coding RNAs (lncRNAs) are believed to participate in diverse biological processes and are emerging as convenient and minimally invasive diagnostic/prognostic/therapeutic markers. The aim of this study was to explore CEBPA-AS1 role and mechanism in OSCC tumorigenesis. In this study, CEBPA-AS1 localized in the cytoplasm and the peri-nuclear cellular compartment functioning as a potential oncogene up-regulated in OSCC was correlated with poor differentiation, lymph node metastasis and high clinical stage, which made it considered to be a prognostic biomarker. Silence of CEBPA-AS1 inhibited OSCC cells proliferation and induced cells apoptosis, migration and invasion by targeting CEBPA and via a novel pathway CEBPA/Bcl2. Our findings provided the first evidence for the lncRNA CEBPA-AS1 regulatory network in OSCC tumorigenesis, which might be helpful to improve the effects of clinical treatment in OSCC.

PMID: 29281558 [PubMed - as supplied by publisher]

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