Micro-RNA149 Confers Taxane Resistance to Malignant Mesothelioma Cells via Regulation of P-glycoprotein Expression.

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Micro-RNA149 Confers Taxane Resistance to Malignant Mesothelioma Cells via Regulation of P-glycoprotein Expression.

Cancer Biol Ther. 2017 Dec 20;:0

Authors: Kenworthy R, Bosco DB, DeLigio JT, Zorio DAR

Abstract
Multidrug resistance (MDR) represents a major hindrance to the efficacy of cancer chemotherapeutics. While surgical resection, radiation, and chemotherapy can be used to reduce tumor size, the subsequent appearance of drug resistant cells is a frequent problem. One of the main contributors to the development of MDR is increased expression of multi-drug resistant protein 1 (MDR1), also known as P-glycoprotein (P-gp). P-gp is a membrane-associated efflux pump that can efficiently remove internalized taxane-base chemotherapeutics thus preventing drug accumulation and maintaining cellular viability. Consequently, investigation into the molecular mechanisms responsible for regulation of P-gp expression is necessary to facilitate treatment of MDR tumors. Using molecular and biochemical approaches, we identified that the micro-RNA, miRNA149, contributes to the development of MDR within malignant mesothelioma cells by regulating the expression of MDR1.

PMID: 29261027 [PubMed - as supplied by publisher]

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