Saving Stem Cells after Stress

Publication date: 7 December 2017
Source:Cell Stem Cell, Volume 21, Issue 6
Author(s): Katherine Y. King
Inflammatory signals can activate hematopoietic stem cells (HSCs), but how HSCs regain quiescence after stress is unclear. In this issue of Cell Stem Cell, Chen et al. (2017) delineate an elegant histamine-dependent feedback mechanism through which myeloid bone marrow cells restore quiescence of myeloid-biased HSCs, with implications for blood disorders, aging, and immunity.

Teaser

Inflammatory signals can activate hematopoietic stem cells (HSCs), but how HSCs regain quiescence after stress is unclear. In this issue of Cell Stem Cell, Chen et al. (2017) delineate an elegant histamine-dependent feedback mechanism through which myeloid bone marrow cells restore quiescence of myeloid-biased HSCs, with implications for blood disorders, aging, and immunity.


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