Dynamic changes in 18 F-borono-L-phenylalanine uptake in unresectable, advanced, or recurrent squamous cell carcinoma of the head and neck and malignant melanoma during boron neutron capture therapy patient selection

Abstract

Background

We evaluated dynamic changes in ¹⁸F–borono-L-phenylalanine (¹⁸F–BPA) uptake in unresectable, advanced, or recurrent squamous cell carcinoma of the head and neck (SCC) and malignant melanoma (MM) during boron neutron capture therapy (BNCT) patient selection.

Methods

Dynamic changes in the maximum standardized uptake value (SUVmax), tumor-to-normal tissue ratio (TNR), and tumor-to-blood pool ratio (TBR) for ¹⁸F–BPA were evaluated in 20 patients with SCC and 8 patients with MM.

Results

SUVmax in SCC tumors decreased significantly from 30 to 120 min. There was a non-statistically significant decrease in SUVmax for SCC tumors from 30 to 60 min and from 60 to 120 min. Patients with MM had nonsignificant SUVmax changes in ¹⁸F–BPA uptake on delayed imaging. Nonsignificant ¹⁸F–BPA TNR and TBR changes were seen in patients with SCC and MM.

Conclusions

Dynamic changes in SUVmax for ¹⁸F–BPA uptake had a washout pattern in SCC and a persistent pattern in MM. Dynamic ¹⁸F–BPA -PET studies should be performed to investigate the pharmacokinetics of ¹⁸F–BPA in humans and select appropriate candidates who may benefit from BNCT.

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