Κυριακή 7 Ιανουαρίου 2018

JCAR015 in ALL: A Root-Cause Investigation [News in Brief]

After conducting an internal probe of the five deaths that halted JCAR015's development for acute lymphoblastic leukemia, Juno Therapeutics has concluded that multiple factors were at play. A surge in inflammatory cytokine levels from rapid, early T-cell proliferation may have provoked the blood–brain barrier disruption seen in these patients, inducing fatal cerebral edema.



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