Response to ‘Perilesional edema in brain cancer: Independent prognosticator or epiphenomenon of biomolecular signature?’

We appreciate the opportunity to respond to the letter by Nardone et al. entitled 'Perilesional edema in brain cancer: independent prognosticator or epiphenomenon of biomolecular signature?' Below, we will discuss 'whether the preoperative edema status is an independent prognosticator or epiphenomenon of biomolecular signature for glioblastomas?', with the emphasis on the survivals and progression patterns after treatment.

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