Efficacy of Larotrectinib in TRK Fusion–Positive Cancers in Adults and Children

The neurotrophic receptor tyrosine kinase genes NTRK1, NTRK2, and NTRK3 encode the tropomyosin receptor kinase (TRK) proteins TRKA, TRKB, and TRKC, respectively. After embryogenesis, TRK expression is limited primarily to the nervous system, where these kinases help regulate pain, proprioception,…

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