Cancers, Vol. 10, Pages 93: The Role of Activator Protein-1 (AP-1) Family Members in CD30-Positive Lymphomas

Cancers, Vol. 10, Pages 93: The Role of Activator Protein-1 (AP-1) Family Members in CD30-Positive Lymphomas

Cancers doi: 10.3390/cancers10040093

Authors: Ines Garces de los Fayos Alonso Huan-Chang Liang Suzanne D. Turner Sabine Lagger Olaf Merkel Lukas Kenner

The Activator Protein-1 (AP-1) transcription factor (TF) family, composed of a variety of members including c-JUN, c-FOS and ATF, is involved in mediating many biological processes such as proliferation, differentiation and cell death. Since their discovery, the role of AP-1 TFs in cancer development has been extensively analysed. Multiple in vitro and in vivo studies have highlighted the complexity of these TFs, mainly due to their cell-type specific homo- or hetero-dimerization resulting in diverse transcriptional response profiles. However, as a result of the increasing knowledge of the role of AP-1 TFs in disease, these TFs are being recognized as promising therapeutic targets for various malignancies. In this review, we focus on the impact of deregulated expression of AP-1 TFs in CD30-positive lymphomas including Classical Hodgkin Lymphoma and Anaplastic Large Cell Lymphoma.

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