Abnormal neuronal response to rectal and anal stimuli in patients treated with primary radiotherapy for anal cancer

Sphincter-sparing radiotherapy or chemoradiation (RT/CRT) have become the standard treatments for most patients with anal cancer. Unfortunately, long-term survivors often suffer from severe bowel symptoms indicating sensory dysfunction. The aim of the present study was to characterize the sensory pathways of the brain–gut axis after radiotherapy for anal cancer.

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