Aluminum Chloride Causes the Dysfunction of Testes Through Inhibiting the ATPase Enzyme Activities and Gonadotropin Receptor Expression in Rats

Abstract

The aim of this experiment is to explore the effects of aluminum chloride (AlCl₃) on the ATPase enzymes and gonadotropin receptors in the testes. Eighty male Wistar rats were orally exposed to 0 mg/kg body weight (BW) (control group, CG), 64 mg/kg BW (low-dose group, LG), 128 mg/kg BW (mid-dose group, MG), or 256 mg/kg BW (high-dose group, HG) for 120 days. The microstructure and ultrastructure of testes; the activities of Na⁺-K⁺-ATPase, Mg²⁺-ATPase, and Ca²⁺-ATPase; and the mRNA and protein expressions of follicle-stimulating hormone receptor (FSHR) and luteinizing hormone receptors (LHR) in the testes were examined. The results showed that the testes histological structure were damaged; the activities of Na⁺-K⁺-ATPase, Mg²⁺-ATPase, and Ca²⁺-ATPase, the mRNA and protein expressions of FSHR and LHR in the testes were all decreased in the rats with AlCl₃ exposure. It indicates that AlCl₃ causes the dysfunction of testes in rats.

from Cancer via ola Kala on Inoreader https://ift.tt/2IqWwES
via IFTTT