Daily IGRT for prostate cancer: Can we stop the train?

We read with interest the phase III randomized trial by Tøndel and colleagues [1] comparing weekly portal imaging and daily CBCT. Specifically, two strategies of IGRT were compared, either daily control to correct for both systematic and random errors or weekly control to correct for systematic error only. Noteworthy, in the weekly IGRT arm, a larger PTV was adopted to reduce the risk of recurrence, but also a rectal block to reduce the risk of toxicity potentially related to the larger PTV of this group of patients.

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