Stem Cell Therapies for Treating Diabetes: Progress and Remaining Challenges

Publication date: 1 June 2018
Source:Cell Stem Cell, Volume 22, Issue 6
Author(s): Julie B. Sneddon, Qizhi Tang, Peter Stock, Jeffrey A. Bluestone, Shuvo Roy, Tejal Desai, Matthias Hebrok
Restoration of insulin independence and normoglycemia has been the overarching goal in diabetes research and therapy. While whole-organ and islet transplantation have become gold-standard procedures in achieving glucose control in diabetic patients, the profound lack of suitable donor tissues severely hampers the broad application of these therapies. Here, we describe current efforts aimed at generating a sustainable source of functional human stem cell-derived insulin-producing islet cells for cell transplantation and present state-of-the-art efforts to protect such cells via immune modulation and encapsulation strategies.

Teaser

Sneddon et al. describe current efforts aimed at generating a sustainable source of functional human stem cell-derived insulin-producing islet cells for cell transplantation for the treatment of diabetes and present state-of-the-art efforts to protect such cells via immune modulation and encapsulation strategies.


https://ift.tt/2JpF2t2