Durable Remissions with Ivosidenib in IDH1-Mutated Relapsed or Refractory AML

Somatic mutations within the conserved active site of isocitrate dehydrogenase (IDH) 1 and 2 occur in multiple tumors, including glioma, acute myeloid leukemia (AML), cholangiocarcinoma, and chondrosarcoma. IDH1 and IDH2 mutations confer a neomorphic enzymatic activity, resulting in the reduction…

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