The New England Journal of Medicine: Search Results in EndocrinologyPituitary-Tumor EndocrinopathiesPituitary adenomas account for approximately 15% of intracranial tumors. Management of these benign tumors requires diagnosis of the specific intrasellar disease and comprehensive, multidisciplinary treatment of local mass effects and peripheral endocrinopathies. Since tumors can produce different…The New England Journal of Medicine: Search Results in EndocrinologyThu Mar 05, 2020 02:00Misguided Changes...
NEJM : ResearchTreatment of Highly Drug-Resistant Pulmonary TuberculosisThe vision of the End TB strategy of the World Health Organization (WHO) is of a world free of tuberculosis by the year 2035. However, extensively drug-resistant (XDR) tuberculosis (i.e. tuberculosis with resistance to isoniazid, rifampin, any fluoroquinolone, and at least one injectable drug…NEJM : ResearchThu Mar 05, 2020 02:00MRI-Targeted, Systematic, and Combined Biopsy for Prostate Cancer DiagnosisThe aggressiveness of...
Science: Current Issue,Learning to deal with dual useScience: Current IssueThu Mar 05, 2020 20:39Bulky lipids for light-harvesting controlScience: Current IssueThu Mar 05, 2020 20:39News at a glanceScience: Current IssueThu Mar 05, 2020 20:39Pervasive functional translation of noncanonical human open reading framesRibosome profiling has revealed pervasive but largely uncharacterized translation outside of canonical coding sequences (CDSs). In this work, we exploit a systematic CRISPR-based screening...
Nature Communications - current - nature.com science feedsAnti-angiogenic effects of VEGF stimulation on endothelium deficient in phosphoinositide recyclingNature Communications - current - nature.com science feedsThu Mar 05, 2020 02:00The electronic structure of benzene from a tiling of the correlated 126-dimensional wavefunctionNature Communications - current - nature.com science feedsThu Mar 05, 2020 02:00A signal cascade originated from epidermis defines apical-basal patterning of Arabidopsis...
Experimental PhysiologySalt‐sensitive hypertension and the immune systemExperimental PhysiologyThu Mar 05, 2020 23:45The effects of hypoxia and fatigue on skeletal muscle electromechanical delayNew Findings What is the central question of this study? The mechanisms underlying impaired muscular endurance and accelerated fatigue during acute hypoxia are incompletely understood. Hypoxia may affect neuromuscular transmission and the muscle membrane, slowing the propagation of myopotentials, compromising...
European Journal of NeuroscienceSelf‐Motion Perception in Parkinson's diseaseAbstract Parkinson's disease (PD), best characterized by its classic motor symptoms, also manifests non‐motor symptoms including perceptual impairments. Normal motor and perceptual brain functions interact continuously in an action‐perception loop, hence perceptual and motor dysfunction in PD are likely also intertwined. A vital skill in order to maintain balance, and to move around in the environment is the ability to...
The New England Journal of Medicine: Search Results in Geriatrics\AgingWhat Are Two Days Worth? Facing Dilemmas Together at the End of LifeMr. J. was 35 years old when he died. He had loved the ocean, playing music, and joking with family and hospital staff alike. As an inpatient palliative care consultant, I took care of him during his last week. Mr. J. had all the makings of a "difficult case": he was young with an invasive pelvic…The New England Journal of Medicine: Search Results in Geriatrics\AgingThu...
Differential expression of nicotinamide N-methyltransferase in primary and recurrent ameloblastomas and odontogenic keratocysts.Related ArticlesDifferential expression of nicotinamide N-methyltransferase in primary and recurrent ameloblastomas and odontogenic keratocysts. Eur J Clin Invest. 2020 Mar 04;:e13220 Authors: Mascitti M, Sartini D, Togni L, Pozzi V, Rubini C, Santarelli A, Emanuelli M Abstract BACKGROUND: Odontogenic tumors are a group of rare heterogeneous diseases that range from hamartomatous...
Pharmaceutics, Vol. 12, Pages 232: Metal Organic Frameworks as Drug Targeting Delivery Vehicles in the Treatment of CancerPharmaceutics, Vol. 12, Pages 232: Metal Organic Frameworks as Drug Targeting Delivery Vehicles in the Treatment of Cancer Pharmaceutics doi: 10.3390/pharmaceutics12030232 Authors: Cai Chen Qin Qu Dong Ni Yin : In recent years, metal organic frameworks (MOFs) have been widely developed as vehicles for the effective delivery of drugs to tumor tissues. Due to the high loading capacity...
Molecules, Vol. 25, Pages 1164: Beneficial Regulation of Cellular Oxidative Stress Effects, and Expression of Inflammatory, Angiogenic, and the Extracellular Matrix Remodeling Proteins by 1α,25-Dihydroxyvitamin D3 in a Melanoma Cell LineMolecules, Vol. 25, Pages 1164: Beneficial Regulation of Cellular Oxidative Stress Effects, and Expression of Inflammatory, Angiogenic, and the Extracellular Matrix Remodeling Proteins by 1α,25-Dihydroxyvitamin D3 in a Melanoma Cell Line Molecules doi: 10.3390/molecules25051164...
Medicina, Vol. 56, Pages 114: Current Endoscopic Management of Malignant Biliary StrictureMedicina, Vol. 56, Pages 114: Current Endoscopic Management of Malignant Biliary Stricture Medicina doi: 10.3390/medicina56030114 Authors: Wang Yang Sung Tsai Biliary and pancreatic cancers occur silently in the initial stage and become unresectable within a short time. When these diseases become symptomatic, biliary obstruction, either with or without infection, occurs frequently due to the anatomy associated...
International Journal of Molecular SciencesIJMS, Vol. 21, Pages 1791: Systems Biology Analysis Reveals Eight SLC22 Transporter Subgroups, Including OATs, OCTs, and OCTNsIJMS, Vol. 21, Pages 1791: Systems Biology Analysis Reveals Eight SLC22 Transporter Subgroups, Including OATs, OCTs, and OCTNs International Journal of Molecular Sciences doi: 10.3390/ijms21051791 Authors: Darcy C. Engelhart Jeffry C. Granados Da Shi Milton H. Saier Jr. Michael E. Baker Ruben Abagyan Sanjay K. Nigam The SLC22 family...
International Journal of Environmental Research and Public HealthIJERPH, Vol. 17, Pages 1690: Quality of Life in POP: Validity, Reliability and Responsiveness of the Prolapse Quality of Life Questionnaire (P-QoL) in Spanish WomenIJERPH, Vol. 17, Pages 1690: Quality of Life in POP: Validity, Reliability and Responsiveness of the Prolapse Quality of Life Questionnaire (P-QoL) in Spanish Women International Journal of Environmental Research and Public Health doi: 10.3390/ijerph17051690 Authors: Sánchez-Sánchez...
Massachusetts Medical Society: New England Journal of Medicine: Table of ContentsBridging Polarization in Medicine — From Biology to Social CausesNew England Journal of Medicine, Volume 382, Issue 10, Page 888-889, March 2020.Massachusetts Medical Society: New England Journal of Medicine: Table of ContentsWed Mar 04, 2020 12:00Treatment of Highly Drug-Resistant Pulmonary TuberculosisNew England Journal of Medicine, Volume 382, Issue 10, Page 893-902, March 2020.Massachusetts Medical Society: New...
Systematic Reviews - Latest ArticlesProtocol for a systematic review and meta-analysis on the effect of hippotherapy and related equine-assisted therapies on motor capabilities in children with cerebral palsyEquine-assisted treatments of the motor system appear to have an effect on the neuromuscular system and aim to improve the pathological condition of children with cerebral palsy. Hippotherapy is a distinct for...Systematic Reviews - Latest ArticlesThu Mar 05, 2020 02:00Mark above section as...
Head and NeckIgE allergy diagnostics and other relevant tests in allergy, a World Allergy Organization position paper.Related ArticlesIgE allergy diagnostics and other relevant tests in allergy, a World Allergy Organization position paper. World Allergy Organ J. 2020 Feb;13(2):100080 Authors: Ansotegui IJ, Melioli G, Canonica GW, Caraballo L, Villa E, Ebisawa M, Passalacqua G, Savi E, Ebo D, Gómez RM, Luengo Sánchez O, Oppenheimer JJ, Jensen-Jarolim E, Fischer DA, Haahtela T, Antila M, Bousquet...
Head and NeckClinicopathological significance of EGFR pathway gene mutations and CRTC1/3-MAML2 fusions in salivary gland mucoepidermoid carcinoma.Related ArticlesClinicopathological significance of EGFR pathway gene mutations and CRTC1/3-MAML2 fusions in salivary gland mucoepidermoid carcinoma. Histopathology. 2020 Mar 04;: Authors: Morita M, Murase T, Okumura Y, Ueda K, Sakamoto Y, Masaki A, Kawakita D, Tada Y, Nibu KI, Shibuya Y, Inagaki H Abstract BACKGROUND: Mucoepidermoid carcinoma (MEC) is...
pubmed: future oncologyProgress in extracellular vesicle biology and their application in cancer medicine.Related ArticlesProgress in extracellular vesicle biology and their application in cancer medicine. Wiley Interdiscip Rev Nanomed Nanobiotechnol. 2020 Mar 04;:e1621 Authors: Srivastava A, Amreddy N, Pareek V, Chinnappan M, Ahmed R, Mehta M, Razaq M, Munshi A, Ramesh R Abstract Under the broader category of extracellular vesicles (EVs), exosomes are now well recognized for their contribution...
pubmed: future oncologyProgress in extracellular vesicle biology and their application in cancer medicine.Related ArticlesProgress in extracellular vesicle biology and their application in cancer medicine. Wiley Interdiscip Rev Nanomed Nanobiotechnol. 2020 Mar 04;:e1621 Authors: Srivastava A, Amreddy N, Pareek V, Chinnappan M, Ahmed R, Mehta M, Razaq M, Munshi A, Ramesh R Abstract Under the broader category of extracellular vesicles (EVs), exosomes are now well recognized for their contribution...
pubmed: cell cycle arrestB7-H3 promotes the cell cycle-mediated chemoresistance of colorectal cancer cells by regulating CDC25A.Related ArticlesB7-H3 promotes the cell cycle-mediated chemoresistance of colorectal cancer cells by regulating CDC25A. J Cancer. 2020;11(8):2158-2170 Authors: Ma Y, Wang R, Lu H, Li X, Zhang G, Fu F, Cao L, Zhan S, Wang Z, Deng Z, Shi T, Zhang X, Chen W Abstract Colorectal cancer (CRC) is one of the most common malignancies, and chemoresistance is one of the key obstacles...
The Journal of laryngology and otology http://goo.gl/Tl02xDVoice outcome after vocal fold injection augmentation with carboxymethyl cellulose versus calcium hydroxyapatite.Related ArticlesVoice outcome after vocal fold injection augmentation with carboxymethyl cellulose versus calcium hydroxyapatite. J Laryngol Otol. 2020 Mar 04;:1-7 Authors: Cohen JT, Benyamini L Abstract BACKGROUND: Vocal fold injection augmentation is a recognised treatment modality for glottic insufficiency. Causes of glottal...
LarynxFibroepithelial Polyp Originating from the Nasal Septum.Related ArticlesFibroepithelial Polyp Originating from the Nasal Septum. Turk Arch Otorhinolaryngol. 2019 Dec;57(4):206-208 Authors: Stoiljkov M, Perić A Abstract Fibroepithelial polyp (FEP) is a rare clinical condition of mesodermal origin, covered usually by squamous epithelium, originating most frequently from the skin, genitourinary and lower respiratory tract. Upper airway FEP is a rare lesion found usually in the pharynx and larynx....
Molecular CarcinogenesisPYCR1 knockdown inhibits the proliferation, migration, and invasion by affecting JAK/STAT signaling pathway in lung adenocarcinomaAbstract Lung adenocarcinoma (LUAD), as a form of non‐small cell lung cancer (NSCLC), is the most frequently diagnosed lung cancer worldwide. To date, a few biomarkers have been reported to provide valuable information in guiding LUAD treatment. The aim of our study was to explore the functional role of pyrroline‐5‐carboxylate reductase 1 (PYCR1)...
Diagnostic CytopathologySplintered tubercular granuloma—A consistent cytological findings in drug defaultersAbstract Background Tuberculosis remains a major health problem in the less developed nations and is now a major health problem in developed countries, owing to the emergence of human immunodeficiency virus (HIV) infection and (AIDS). However, despite the availability of effective chemotherapy, patient noncompliance with regimens is the most common reason for therapeutic failures. The aim...
Allergy and Clinical ImmunologyInformation for ReadersPublication date: March 2020Source: Journal of Allergy and Clinical Immunology, Volume 145, Issue 3Author(s):Allergy and Clinical ImmunologyThu Mar 05, 2020 17:43The sense of smell in chronic rhinosinusitisPublication date: March 2020Source: Journal of Allergy and Clinical Immunology, Volume 145, Issue 3Author(s): Joaquim Mullol, Franklin Mariño-Sánchez, Meritxell Valls, Isam Alobid, Concepció MarinAllergy and Clinical ImmunologyThu Mar 05, 2020...
G3: Genes, Genomes, Genetics current issueAbsence of a Faster-X Effect in Beetles (Tribolium, Coleoptera)The faster-X effect, namely the rapid evolution of protein-coding genes on the X chromosome, has been widely reported in metazoans. However, the prevalence of this phenomenon across diverse systems and its potential causes remain largely unresolved. Analysis of sex-biased genes may elucidate its possible mechanisms: for example, in systems with X/Y males a more pronounced faster-X effect in male-biased...
pubmed: sleepA-phase classification using convolutional neural networks.Related ArticlesA-phase classification using convolutional neural networks. Med Biol Eng Comput. 2020 Mar 02;: Authors: Arce-Santana ER, Alba A, Mendez MO, Arce-Guevara V Abstract A series of short events, called A-phases, can be observed in the human electroencephalogram (EEG) during Non-Rapid Eye Movement (NREM) sleep. These events can be classified in three groups (A1, A2, and A3) according to their spectral contents, and...
pubmed: philosophy for medic...Patient and Caregiver Priorities for Outcomes in Peritoneal Dialysis: Multinational Nominal Group Technique Study.Related ArticlesPatient and Caregiver Priorities for Outcomes in Peritoneal Dialysis: Multinational Nominal Group Technique Study. Clin J Am Soc Nephrol. 2019 01 07;14(1):74-83 Authors: Manera KE, Johnson DW, Craig JC, Shen JI, Ruiz L, Wang AY, Yip T, Fung SKS, Tong M, Lee A, Cho Y, Viecelli AK, Sautenet B, Teixeira-Pinto A, Brown EA, Brunier G, Dong J,...
pubmed: philosophy for medic...The Nerve to Thyrohyoid Muscle as a Novel Donor Nerve for Laryngeal Reinnervation.Related ArticlesThe Nerve to Thyrohyoid Muscle as a Novel Donor Nerve for Laryngeal Reinnervation. Ann Otol Rhinol Laryngol. 2020 Apr;129(4):355-360 Authors: Graham ME, Smith ME Abstract OBJECTIVES: Recurrent laryngeal nerve (RLN) injury may be a consequence of surgical procedures of the skull base, neck, and chest, with adverse consequences to function and quality of life. Laryngeal...
Laryngology and otologyThe use of modified Silastic nasal splints as frontal sinus stents: a technical note.Related ArticlesThe use of modified Silastic nasal splints as frontal sinus stents: a technical note. J Laryngol Otol. 2020 Mar 03;:1-2 Authors: Shahidi S, Jama GM, Ahmed SK Abstract BACKGROUND: Endoscopic frontal sinus surgery is frequently complicated by post-operative stenosis and obstruction of the frontal sinus outflow tract, resulting in recurrent disease. Frontal sinus stents may help...
77.Int Forum Allergy Rhinol. 2019 May;9(5):466-472. doi: 10.1002/alr.22275. Epub 2019 Jan 15.Sinonasal risk factors for eustachian tube dysfunction: Cross-sectional findings from NHANES 2011-2012.Juszczak H1, Aubin-Pouliot A2, Sharon JD2, Loftus PA2.Author informationAbstractBACKGROUND:Sinonasal pathology is frequently cited as a cause of eustachian tube dysfunction (ETD), despite a lack of evidence. Using a large, nationally representative sample, we investigated whether abnormal tympanometry, an...
44.Nutrients. 2020 Feb 29;12(3). pii: E665. doi: 10.3390/nu12030665.A Review of Zinc-L-Carnosine and Its Positive Effects on Oral Mucositis, Taste Disorders, and Gastrointestinal Disorders.Hewlings S1, Kalman D2.Author informationAbstractZinc-L-carnosine (ZnC), also called polaprezinc known as PepZin GI™, is a chelated compound that contains L-carnosine and zinc. It is a relatively new molecule and has been associated with multiple health benefits. There are several studies that support ZnC's benefits...
1.Oral Cavity, Pharyngeal, and Laryngeal Cancer Prevention (PDQ®): Health Professional Version.AuthorsPDQ Screening and Prevention Editorial Board.SourcePDQ Cancer Information Summaries [Internet]. Bethesda (MD): National Cancer Institute (US); 2002-.2020 Feb 27.ExcerptThis PDQ cancer information summary for health professionals provides comprehensive, peer-reviewed, evidence-based information about oral cavity, oropharyngeal, nasopharyngeal, hypopharyngeal, and laryngeal cancer prevention. It is...
Modified wafer for orthognathic surgery in partially edentulous patients: We present a modified wafer for mandibular orthognathic surgery in a partially edentulous 49-year-old woman. To the best of our knowledge, this technique has not been reported previously, and it was effective with an operating time that was comparable to similar operations in dentate patients. (Source: The British Journal of Oral and Maxillofacial Surgery)
Palmatine alleviates hyperalgesia by inhibiting the expression of calcitonin gene-related peptide in the trigeminal ganglion of rats with chronic constriction injury of the infraorbital nerve: Trigeminal neuralgia is one of the most common of the neuropathic pains, and it can seriously influence patients ' quality of life. Calcitonin gene-related peptide (CGRP) is a type of nociceptive neurotransmitter that is expressed in neurons of the trigeminal ganglion and plays a major part in transmitting...
Simultaneous maxillomandibular distraction in unilateral mandibular hypoplasia: In craniomaxillofacial surgery we often deal with hypoplastic mandibles and mandibular asymmetries, the correction of which is critical to obtaining acceptable aesthetic results. In all of them we find common skeletal problems once growth has finished, such as an inclined occlusal plane and facial asymmetry with a stable dental occlusion. Simultaneous maxillomandibular distraction, which involves a Le Fort I osteotomy...
Oromandibular dystonia: a diagnosis not to miss: Oromandibular dystonia (OMD) is characterised by sustained or repetitive involuntary movements of the jaw, face, and tongue. People with the condition may present to their dentist, general practitioner, or a secondary care specialist with non-specific symptoms including jaw or facial pain, bruxism, subluxations or dislocations of the jaw; fractured teeth or dental restorations, or both; or jaw tremor. Many clinicians are not aware of the disorder and...
Botulinum toxin in the management of temporomandibular disorders: a systematic review: The aim of this review was to critically investigate and assess the evidence relating to the use and efficacy of botulinum toxin (BTX) in the management of temporomandibular joint disorders (TMD) and masticatory myofascial pain. A comprehensive search was conducted of PubMed, Scopus, Embase, and Cochrane CENTRAL, to find relevant studies from the last 30 years up to the end of July 2018. Seven were identified....
Lipofilling of the upper eyelid to treat paralytic lagophthalmos: Lagophthalmos is one of the most unpleasant and dangerous conditions that affect patients with facial palsy. The lack of ocular protection leads to corneal problems (such as conjunctival infections, acute and chronic keratitis, corneal ulcerations, and blindness). A dynamic reanimation of blinking eyelids is the therapeutic gold standard. However, success is not guaranteed with these dynamic techniques; even if results are good, blinking...
Calcinosis cutis: A 32-year-old African-Caribbean woman presented with multiple painful areas of the face and neck that were discharging pus and 'gritty' material (Fig. 1). Her medical history included lupus and Raynaud's disease. On examination, we noted tender, firm, multiple swellings of the bilateral temple and the submental and submandibular regions, and discharging sinuses. Computed tomography (CT) of the craniofacial region show ed multifocal dermal and subdermal deposits of calcium (Fig....
Current perspectives on the surgical management of mandibular third molars in the United Kingdom: the need for further research: This survey of expert opinion regarding the management of mandibular third molar (M3M) impaction and its clinical sequelae was circulated to all members of the British Association of Oral and Maxillofacial Surgeons (BAOMS). It was completed by 289 clinicians who reported treating 60003 patients annually. Respondents included 199 (69%) specialists and 58 (20%) primary care...
Intraparotid node metastases in adults with parotid mucoepidermoid cancer: an indicator of prognosis?: We have retrospectively analysed the predictive value of intraparotid nodal metastases in patients having neck dissection for parotid mucoepidermoid cancer. The main outcomes were intraparotid nodal metastases, a new system for staging metastatic parotid nodes, and recurrence-free survival. The overall rate of intraparotid metastasis was 30/122 (25%), and seven patients had deep parotid nodal metastases....
Alimentary Pharmacology & TherapeuticsAdult height in patients with childhood‐onset inflammatory bowel disease: a nationwide population‐based cohort studySummary Background Growth retardation is well described in childhood‐onset inflammatory bowel disease (IBD). Aims To study if childhood‐onset IBD is associated with reduced final adult height. Methods We identified 4201 individuals diagnosed with childhood‐onset IBD 1990‐2014 (Crohn's disease: n = 1640; ulcerative colitis: n = 2201 and IBD‐unclassified...
From strawberry gingivitis to palatal perforation: the clinicopathological spectrum of oral mucosal lesions in granulomatosis with polyangiitis: AbstractBackgroundReports of oral manifestations of granulomatosis with polyangiitis usually refer to single‐case reports; "strawberry gingivitis" has been increasingly reported.ObjectiveTo study the clinicopathological findings of four patients in which the diagnosis of granulomatosis with polyangiitis was suspected from the observation of their oral lesions...
Latest Results for TrialsVerifying participant-reported clinical outcomes: challenges and implicationsAbstract Background Researchers often rely on trial participants to self-report clinical outcomes (for example, fractures, re-operations). Little information exists as to the 'accuracy' of participant-reported clinical outcomes, particularly in randomised controlled trials (RCTs). To help address this evidence gap, we report four case studies, nested within different RCTs where participant-reported...
A multicenter randomized trial of personalized acupuncture, fixed acupuncture, letrozole, and placebo letrozole on live birth in infertile women with polycystic ovary syndrome: AbstractBackgroundTraditional Chinese medicine (TCM) usually involves syndrome differentiation and treatment. Acupuncture, one form of TCM, requires the selection of appropriate acupoints and needling techniques, but many clinical trials on acupuncture have used fixed acupuncture protocols without accounting for individual...
A Community-based Assessment of Skin Care, Allergies, and Eczema (CASCADE): an atopic dermatitis primary prevention study using emollients—protocol for a randomized controlled trial: AbstractBackgroundAtopic dermatitis (AD) is a common, chronic skin disorder often beginning in infancy. Skin barrier dysfunction early in life serves as a central event in the pathogenesis of AD. In infants at high risk of developing AD, preventative application of lipid-rich emollients may reduce the risk of developing...
Latest Results for Fluids and Barriers of the CNSSecondary deterioration in patients with normal pressure hydrocephalus after ventriculoperitoneal shunt placement: a proposed algorithm of treatmentAbstract Background After ventriculoperitoneal shunt surgery for idiopathic normal pressure hydrocephalus (iNPH) with adjustable gravitational valves, a certain proportion of patients develop secondary clinical worsening after initial improvement of clinical symptoms. The aim of this study was to analyze...
Post-extubation stridor after prolonged intubation in the pediatric intensive care unit (PICU): a prospective observational cohort study: AbstractPurposeProlonged endotracheal intubation may lead to laryngeal damage, with stridor being the most relevant clinical symptom. Our objective was to determine the incidence of post-extubation stridor and their clinical consequences in children within a tertiary referral center and to identify contributing factors.Methods150 children, aged 0–16 years, intubated...
Clinical parameters predicting tonsillar malignancy: AbstractPurposeTonsillectomy is indicated in unilateral tonsillar enlargement (UTE) to rule out malignancy, which eventually is found in about 1.4% of the patients. The aim of this study was to evaluate the presenting symptoms of patients who underwent tonsillectomy for UTE and identify parameters that are associated with an increased risk for malignancy, for better assessment and refinement of current management protocols.MethodsA retrospective...
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