The respiratory tract is a common entry point into the human body for both allergens and natural/manmade carcinogens, the latter of which could result in lung, gastrointestinal, and other malignancies.(1) We previously determined, in analyzing data from the National Health Interview Survey (NHIS) that there was a significant negative relationship between diagnoses of cancer with allergic rhinitis or asthma. The obstruction associated with both allergic rhinitis and asthma may act to block the entry of both allergens and carcinogens.(2) Although other studies have examined the relationship between personal cancer diagnoses in asthmatic or allergic individuals, or via biomarkers such as IgE, (3, 4), the heritability of such an effect, which may provide a survival benefit, has not been evaluated through family studies.
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