Laminins and interaction partners in the architecture of the basement membrane at the dermal‐epidermal junction

xlomafota13 shared this article with you from Inoreader Laminins and interaction partners in the architecture of the basement membrane at the dermal‐epidermal junction Via Experimental Dermatology Abstract The basement membrane at the dermal‐epidermal junction keeps the epidermis attached to the dermis. This anatomical barrier is made up of four categories of extracellular matrix proteins: collagen IV, laminin, nidogen and perlecan. These proteins are precisely arranged in a well‐defined architecture through specific interactions between the structural domains of the individual components. Some of the molecular constituents are provided by both fibroblasts and keratinocytes, while others are synthesized exclusively by fibroblasts or keratinocytes. It remains to be determined how the components from the fibroblasts are targeted to the dermo‐epidermal junction and correctly organized and integrated with the proteins from the adjacent keratinocytes to form the basement membrane. View on the web Inoreader. Take back control of your news feed. Follow us on Twitter and Facebook.