Distinct immunologic endotypes are associated with clinical trajectory after severe blunt trauma and hemorrhagic shock

xloma.fota13 shared this article with you from Inoreader Distinct immunologic endotypes are associated with clinical trajectory after severe blunt trauma and hemorrhagic shock Via Journal of Trauma and Acute Care Surgery - Current Issue BACKGROUND The genomic/cytokine "storm" after severe trauma is well described. However, the differing composition, magnitude and resolution of this response, and its relationship to clinical outcomes remain unclear. METHODS This is a secondary analysis of a prospective longitudinal cohort study of severely injured trauma patients in hemorrhagic shock. Peripheral blood sampling was performed at 0.5, 1, 4, 7, 14, and 28 days after injury for measurement of circulating immune biomarkers. K-means clustering using overall mean and trajectory slope of selected immunologic biomarkers were used to identify distinct temporal immunologic endotypes. Endotypes were compared with known clinical trajectories defined as early death ( View on the web Inoreader. Take back control of your news feed. Follow us on Twitter and Facebook.