The effect of N-acetyl cysteine on biofilm layers in an experimental model of chronic otitis media.

xlomafota13 shared this article with you from Inoreader The effect of N-acetyl cysteine on biofilm layers in an experimental model of chronic otitis media. Via Acta Otorhinolaryngol Ital Related Articles The effect of N-acetyl cysteine on biofilm layers in an experimental model of chronic otitis media. Acta Otorhinolaryngol Ital. 2020 Dec;40(6):457-462 Authors: Ersoy ÃallıoÄlu E, Berçin S, BaÅdemir G, KiriÅ M, Tatar Ä°, Tuzuner A, OÄuzhan T, Müderris T, Sargon MF, Korkmaz MH Abstract Objectıve: The aim of this study was to investigate the efficacy of N-acetylcysteine (NAC) on biofilm layers and on the course of disease in chronic otitis media. Methods: Twenty-five rats that were induced with chronic otitis media (COM) were separated into three groups. In Group 1 (N = 18), 0.2% ciprofloxacin + 0.1% dexamethasone sodium phosphate + 0.5 mg/ml NAC solution was locally injected to the right ear of the rats; in Group 2, (N=18) 0.2% ciprofloxacin + 0.1% dexamethasone sodium phosphate was locally injected to the left ear of the rats. No treatment was applied to either ear of rats in Group 3 (N = 5). Histopathological and scanning electron microscope (SEM) evaluations were performed in all groups. Results: SEM revealed biofilm formation in all COM induced groups. No significant difference was seen between groups 1 and 2 in terms of suppuration levels, fibrosis, inner ear involvement, infection staging and biofilm formation (p > 0.05). Conclusıons: In this study, while histopathological and SEM evaluation revealed no effect of 0.5 mg/ml NAC on the biofilm layer in COM-induced rats, further studies with NAC at different concentrations are still needed on different types of experimental animals. PMID: 33558775 [PubMed - in process] View on the web Inoreader. Take back control of your news feed. Follow us on Twitter and Facebook.