Role of NGF and its receptors in wound healing (Review)

xlomafota13 shared this article with you from Inoreader Role of NGF and its receptors in wound healing (Review) Via Experimental and therapeutic medicine Exp Ther Med. 2021 Jun;21(6):599. doi: 10.3892/etm.2021.10031. Epub 2021 Apr 11. ABSTRACT Wound healing is an important and complicated process that includes four highly integrated and overlapping phases, haemostasis, inflammation, proliferation and tissue remodelling. Nerve growth factor (NGF) was the first member of a family of neurotrophic factors to be discovered, and is an essential neurotrophic factor for the development and maintenance of the central and peripheral nervous systems. Several studies have proposed that NGF and its receptors, tropomyosin-related kinase receptor 1 and NGF receptor, are involved in the wound healing process, and are important components of the healing of several wounds both in vivo and in vitro. Topical application of NGF significantly promotes the healing of different types of wounds, including diabetic foot ulcers, pressure ulcers and corneal wounds. The present review summarizes the s tatus of NGF and its receptors in current literature, and discusses data obtained in the last few years on the healing action of NGF in cutaneous, corneal and oral wounds. PMID:33884037 | PMC:PMC8056114 | DOI:10.3892/etm.2021.10031 View on the web Inoreader. Take back control of your news feed. Follow us on Twitter and Facebook.