Natural killer cells: of-the-shelf cytotherapy for cancer immunosurveillance

xlomafota13 shared this article with you from Inoreader Natural killer cells: of-the-shelf cytotherapy for cancer immunosurveillance Via American Journal of Cancer Research Am J Cancer Res. 2021 Apr 15;11(4):1770-1791. eCollection 2021. ABSTRACT Natural killer (NK) cells are advantaged innate cytotoxic lymphocytes with characteristics of tumor immunosurveillance and microorganism elimination. Distinguish from the adaptive T and B lymphocytes, the autologous or allogeneic NK cells efficaciously fulfil the function of combating transformed hematological malignancies and metastatic solid tumors via the proverbial mechanisms including direct cytolytic effect and antibody-dependent cell-mediated cytotoxicity (ADCC) as well as paracrine effects dispense with antigen presentation. Herein, we review the candidate sources (e.g., peripheral blood, umbilical cord blood, placental blood, cell lines and stem cells) for large-scale and clinical-grade NK cell manufacturing, ex vivo cultivation (feeder-, cytokine cocktail- or physicochemical irritation-dependent strategies) for NK cell persistence and activation. Further more, we also figure out the promising prospects as well as the accompanied challenges of NK cell- or chimeric antigen receptor-transduced NK (CAR-NK) cell-based adoptive immunotherapy in standardizations for industrialized preparation and clinical practices. PMID:33948388 | PMC:PMC8085843 View on the web Inoreader. Take back control of your news feed. Follow us on Twitter and Facebook.